PCORI Funding Clinical Trials

On January 16, 2018, the Patient-Centered Outcomes Research Institute (PCORI) https://www.pcori.org announced that PCORI will be funding pragmatic clinical trials, large simple trials, or large-scale observational studies to evaluate patient-centered outcomes. These studies will compare two or more alternatives for addressing prevention, diagnosis, treatment, or in managing disease or symptoms.

The award funding ceiling is $10,000,000 with total funding available for $90,000,000 with the project expected to take up to five years. A letter of intent must be submitted by February 13, 2018 to https://pcori.force.com/engagement. Selected applicants will be invited to submit a full proposal with a deadline of May 16, 2018.

Proposed studies must address critical clinical choices faced by patients, their caregivers, clinicians, or delivery systems. The studies must involve a broadly representative patient population and be large enough to provide precise estimates of hypothesized effectiveness differences and evaluate the potential differences in treatment effectiveness in patient subgroups.

Applications may be submitted by any private sector research organization, including any nonprofit or for-profit organization, any public-sector research organization including any university or college hospital or healthcare system any laboratory or manufacturer, or unit of local, state, or federal government.

Sixteen high priority topics and research questions have been identified by PCORI’s multi-stakeholder panels. A few of the high priority topics include:

  • Integration of mental and behavioral health services into the primary care of persons at risk for disparities in healthcare and outcomes
  • Remote delivery approaches for treating depression with anxiety
  • Improving outcomes in mothers and babies at risk for disparities by comparing evidence-based models of perinatal care
  • Strategies to improve dental care in children in medically underserved areas
  • Strategies to improve post-hospital discharge outcomes by integrating pharmacists into the care team


Go to https://www.pcori.org/sties/default/files/PCORI-PFA-2018-Cycle-1-Pragmatic-Studies.pdf for more details on the sixteen high priority topics by going to page 24 in the PFA Appendix. For inquiries, go to www.pcori.org/PFA/inquirypfa@pcori.org

For more details, call the help desk at 201-627-1885.

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