The National Institute of Nursing Research (NINR) within NIH intends to contract with Inova Fairfax Hospital in Fairfax, Virginia. The funding will used to study the biological mechanisms underlying the risks that can produce the onset of PTSD as well as long lasting neurological impairments.
Data will be obtained from clinical procedures and medical records as part of standard of care to determine the patient’s eligibility. Recruitment will be for 120 patients to be enrolled over year with an average of 10 patients enrolled per month. NINR will then categorize patients into two groups. One group will include trauma patients who do not develop PTSD and the other group will include trauma patients who do develop PTSD.
Specifically, this study will identify differences in the DNA methylation of stress-related genes and concentrations of inflammatory proteins that collect in blood and sweat that may contribute to a higher risk for PTSD onset. Blood for research will be taken when phlebotomy is done for clinical evaluation and/or treatment or in conjunction with clinical care.
This notice appearing April 2, 2013 at www.fbo.gov is not a request for proposals but a capability statement, proposal, or quotation may be submitted by other sources by April 17, 2013. Primary point of contact is Louis A. Kuta, Sr. at kutal@od.nih.gov.